The Madonna with saints in front of a landscape was a motif of which Palma, who was active in Venice from 1510 on, created numerous variants characterized by their highly narrative and atmospheric quality. He sold this kind of sacre conversazioni, thematically customized to the donor’s wishes, with notable success among his extensive circle of clients. The painting’s main focus is on the Christ Child offering the rosary to the patron saint of plague victims. The female saint can be identified as the early Christian martyr Aurea by her golden robe and the palm branch.